Selected Peer-Reviewed Publications:

1. Wei R. Chen, Robert L. Adams, Sean Heaton, D. Thomas Dickey, Kenneth E. Bartels and Robert E. Nordquist, "Chromophore-enhanced laser-tumor tissue photothermal interaction using 808 nm diode laser", Cancer Letters, 88, 15-19, 1995.

2. Wei R. Chen, Robert L. Adams, Kenneth E. Bartels and Robert E. Nordquist, “Chromophore-enhanced in vivo tumor cell destruction using an 808-nm diode laser”, Cancer Letters, 94, 125-131, 1995.

3. Wei R. Chen, Robert L. Adams, Aaron K. Higgins, Kenneth E. Bartels and Robert E. Nordquist, “Photothermal effects on murine mammary tumors using indocyanine green and an 808-nm diode laser: An in vivo efficacy study”, Cancer Letters, 98, 169-173, 1996.

4. Wei R. Chen, Robert L. Adams, Raoul Carubelli and Robert E. Nordquist, “Laser-photosensitizer assisted immunotherapy: A novel modality in cancer treatment”, Cancer Letters, 115, 25-30, 1997.

5. Li-hong Wang, Robert E. Nordquist and Wei R. Chen, “Optimal beam size for light delivery to absorption-enhanced tumors buried in biological tissues and effect of multiple beam delivery: a Monte Carlo study”, Applied Optics Vol. 36, 8286-8291, 1997.

6. Wei R. Chen, Wei-Guo Zhu, Joseph R. Dynlacht, Hong Liu and Robert E. Nordquist, “Long-term tumor resistance induced by laser photo-immunotherapy”, International Journal of Cancer, 81, 808-812, 1999.

7. Fang Xu, Hong Liu, Xizeng Wu, Hangyi Jiang, Robert E. Nordquist and Wei R. Chen, “Measurement of x-ray attenuation coefficients of aqueous solutions of indocyanine green and glycated chitosan”, Medical Physics, 26, 1371-1374, 1999.

8. Wei R. Chen, Hong Liu, John A. Nordquist and Robert E. Nordquist, “Tumor cell damage and leukocyte infiltration after laser immunotherapy treatment”, Lasers in Medical Science, 15, 43-48, 2000.

9. Wei R. Chen, Anil K. Singhal, Hong Liu, and Robert E. Nordquist, “Laser immunotherapy induced antitumor immunity and its adoptive transfer”, (Advances in Brief) Cancer Research, 61, 459-461, 2001.

10. Wei R. Chen, Hong Liu and Robert E. Nordquist, “Dynamically observing intratumor injection of laser-absorbing dye and immunoadjuvant using digital x-ray imaging technique”, Optical Engineering, Vol. 40 (7), 1249-1254, 2001.

11. Wei R. Chen, Jerry W. Ritchey, Kenneth E. Bartels, Hong Liu, and Robert E. Nordquist, “Effect of different components of laser immunotherapy in treatment of metastatic tumors in rats”, Cancer Research, 62 4295-4299, 2002.

12. Vinson G. Liu, Thomas M. Cowan, Sang-Won Jeong, Steven L. Jacques, Evan C. Lemley and Wei R. Chen, “Selective photothermal interaction using an 805-nm diode laser and indocyanine green in gel phantom and chicken breast tissue”, Lasers in Medical Science, Vol. 17 No. 4, 272-279, 2002.

13. Wei R. Chen, Hong Liu, Raoul Carubelli and Robert E. Nordquist, “Synergistic Effect of Photothermal and Photoimmunological Reactions in Treatment of Metastatic Tumors”, Journal of X-Ray Science and Technology, 10, 225-235, 2002.

14. Michael D. Lucroy, Wei R. Chen, Tisha D. Ridgway, Russell G. Higbee, and Kenneth E. Bartels, “Selective laser-induced hyperthermia for the treatment of spontaneous tumors in dogs”, Journal of X-Ray Science and Technology, 10, 237-243, 2002.

15. D. Richard Ishmael, Wei R. Chen, John Nordquist, Hong Liu, and Robert E. Nordquist, “Synergistic Effect of Sequential Administration of Mitoguazone (MGBG) and Gemcitabine in Treating Tissue Cultured Human Breast Cancer Cells and Mammary Rat Tumors”, Cancer Investigation, 21, 217-226, 2003.

16. D. Richard Ishmael, Wei R. Chen, Steven A. Hamilton, Hong Liu, and Robert E. Nordquist, “A Phase I Human Trial of Mitoguazone and Gemcitabine Sequential Bi-Weekly Treatment of Cancer Patients”, Cancer Investigation, 21, 542-549, 2003.

17. Wei R. Chen, Raoul Carubelli, Hong Liu, and Robert E. Nordquist, “Laser Immunotherapy: A Novel Treatment Modality for Metastatic Tumors”, Molecular Biotechnology, 25, 37-43, 2003.

18. Wei R. Chen, Raoul Carubelli, Hong Liu, and Robert E. Nordquist, “Detection of Anti-Tumor Immunity Induced by Laser Immunotherapy”, Molecular Biotechnology, 25, 45-51, 2003.

19. Wei R. Chen, Sang Won Jeong, Michael D. Lucroy, Roman F. Wolf, Eric W. Howard, Hong Liu, and Robert E. Nordquist, “Induced anti-tumor immunity against DMBA-4 metastatic mammary tumors in rats using a novel approach”, International Journal of Cancer, 107 (6), 1053-1057, 2003.

20. Christopher A. Bailey, Thomas M. Cowan, Vinson G. Liu, Evan C. Lemley, and Wei R. Chen, “Optimization of Selective Hyperthermia”, Journal of Biomedical Optics, 9 (3), 648-654, 2004.

21. Hemanth Athiraman, Roman F. Wolf, Kenneth E. Bartels, Suman Shivakoti, Hong Liu, and Wei R. Chen, “Selective Photothermal Tissue Interaction Using 805-nm Laser and Indocyanine Green in Tissue welding”, Journal of X-Ray Science and Technology, 12, 117-126, 2004.

22. Wei R. Chen, Mladen Korbelik, Kenneth E. Bartels, Hong Liu, Jinghai Sun, and Robert E. Nordquist, “Enhancement of laser cancer treatment by a chitosan-derived immunoadjuvant”, Photochemistry and Photobiology, 81, 190-195, 2005.

23. D. Richard Ishmael, Hong Liu, John A. Nordquist, Robert E. Nordquist, and Wei R. Chen, “Phase I Trial of Concurrent Administration of Topotecan and Docetaxel for Cancer Treatment”, Journal of Applied Research, 5, 53-60, 2005.

24. Yueqing Gu, Wei R. Chen, Mengna Xia, Sang Won Jeong and Hanli Liu, “Effects of Photothermal Therapy on Breast Tumor Vascular Contents: Noninvasive Monitoring by Near-Infrared Spectroscopy”, Photochemistry and Photobiology, 81, 1002-1009, 2005.

25. Wei R. Chen, Zheng Huang, Mladen Korbelik, Robert E. Nordquist, and Hong Liu, “Photoimmunotherapy for Cancer Treatment”, Journal of Environmental Pathology, Toxicology and Oncology, 25, 281-291, 2006.

26. Zheng Huang, Qian Yong Gang and Wei R. Chen “Photodynamic Therapy and Anti-tumor Immune Responses”, Chinese Journal of Laser Medicine and Surgery, 15 (2), 121-124, 2006 (in Chinese).

27. Yunxia Wu, Da Xing, and Wei R. Chen, “Dynamic Monitoring of Photofrin-PDT Induced Apoptosis Using FRET Technique”, Cell Cycle, 5:7, 720-734, 2006.

28. Jared J. Crochet, Surya C Gnyawali, Yichao Chen, Evan C. Lemley, Lihong V. Wang and Wei R. Chen, “Temperature Distribution in Selective Laser-Tissue Interaction”, Journal of Biomedical Optics, Vol. 11, 034031, 1-10, 2006.

29. Wei R. Chen and Zheng Huang, “Biophotonics and Immune Responses – Highlights from a new SPIE Photonics West Conference (BIOS 2006)”, Photodiagnosis and Photodynamic Therapy, Vol. 3, 184-189, 2006.

30. Wei R. Chen, Kenneth E. Bartels, Hong Liu, and Robert E. Nordquist, “Laser-Photothermal Effect on Skin Tissue – Damage and Recovery”, Journal of X-Ray Science and Technology, 14, 207-215, 2006.

31. Mark F. Naylor, Wei R. Chen, T. Kent Teague, Lisa Perry, and Robert E. Nordquist, “In Situ Photo Immunotherapy: A Tumor-Directed Treatment Modality for Melanoma”, British Journal of Dermatology, 155, 1287-1292, 2006.

32. Yinyuan Wu, Da Xing, Lei Liu, Tongsheng Chen, and Wei R. Chen, “Fluorescence Resonance Energy Transfer Analysis of Bid Activation in Living Cells during Ultraviolet-induced Apoptosis”, Acta Biochimica et Biophysica Sinica, 39 (1), 37–45, 2007.

33. Feng Wu, Lan Zhou, and Wei R. Chen, “Host antitumour immune responses to HIFU ablation”, International Journal of Hyperthermia, 23(2): 165–171, 2007.

34. Liangzhong Xiang, Da Xing, Huaimin Gu, Diwu Yang, Sihua Yang, Lvming Zeng, and Wei R. Chen, “Real-time optoacoustic monitoring of vascular damage during photodynamic therapy treatment of tumor”, Journal of Biomedical Optics, Vol 12, 014001 (Feb) 2007.

35. Feng Wu, Gail ter Haar, and Wei R. Chen, “High-intensity focused ultrasound ablation of breast cancer”, Expert Review of Anticancer Therapy, Vol 7, No. 6, 823-831, 2007.

36. Tongsheng Chen, Jinjun Wang, Da Xing, and Wei R. Chen, “Spatio-Temporal Dynamic Analysis of Bid Activation and Apoptosis Induced by Alkaline Condition in Human Lung Adenocarcinoma Cell”, Cellular Physiology and Biochemistry, Vol. 20, 569-578, (DOI:10.1159/000107540), 2007.

37. Shengnan Wu, Da Xing, Fang Wang, Tongsheng Chen, and Wei R. Chen, “Mechanistic Study of Apoptosis Induced by High Fluence Low Power Laser Irradiation Using Fluorescence Imaging Techniques”, Journal of Biomedical Optics, Vol. 12, 064015 (1-10), 2007.

38. Sihua Yang, Da Xing, Yeqi Lao, Diwu Yang, Lvming Zeng, Liangzhong Xiang, and Wei R. Chen, “Noninvasive monitoring of traumatic brain injury and post-traumatic rehabilitation with laser-induced photoacoustic imaging”, Applied Physics Letters, 90, 243902 (1-3), 2007.

39. Yinyuan Wu, Da Xing, Wei R. Chen, and Xichao Wang, “Bid is not required for Bax translocation during UV-induced apoptosis”, Cellular Signalling, Vol. 19 (12) 2468-2478, 2007.

40. Surya C. Gnyawali, Yichao Chen, Feng Wu, Kenneth E. Bartels, James P. Wicksted, Hong Liu, and Wei R. Chen, “Temperature Measurement on Tissue Surface during Laser Irradiation”, Medical and Biological Engineering and Computing, Vol. 46, 159-168, 2008.

41. Lei Liu, Da Xing, Wei R. Chen, Tongsheng Chen, Yihui Pei, and Xuejuan Gao,“Calpain-mediated pathway dominates cisplatin-induced apoptosis in human lung adenocarcinoma cells as determined by real-time single cell analysis”, International Journal of Cancer, 122, 2210-2222, 2008.

42. Abby Deans, Linda Hess, Michael Koss, Hong Liu, and Wei R. Chen, “Laser Photothermal Effects on Tumor Vasculature Using Laser Doppler Flowmetry”, Journal of X-Ray Science and Technology, 16, 51-57, 2008.

43. Feifan Zhou, Da Xing, and Wei R. Chen, “Dynamics and mechanism of HSP70 translocation induced by photodynamic therapy treatment”, Cancer Letters, 264, 135-144, 2008.

44. Debin Zhu, Yabing Tang, Da Xing^, and Wei R. Chen, “PCR-free quantitative detection of genetically modified organism from raw materials. An electrochemiluminescence-based bio bar code method”, Analytical Chemistry, 80, 3566-3571, 2008.

45. Yichao Chen, Surya C. Gnyawali, Feng Wu, Hong Liu, Yasvir A. Tesiram, Andrew Abbott, Rheal A. Towner, and Wei R. Chen, “Magnetic resonance imaging guidance for laser photothermal therapy”, Journal of Biomedical Optics, Vol. 13, 044033, 2008.

46. Feifan Zhou, Da Xing, Zhongmin Ou, Baoyan Wu, Daniel E. Resasco, and Wei R. Chen, “Cancer photothermal therapy in the near-infrared region by using single-walled carbon nanotubes”, Journal of Biomedical Optics, 14, 021009, 2009.

47. Lifang Liang, Xichao Wang, Da Xing, Tongsheng Chen, and Wei R. Chen, “Noninvasive Determination of Cell Nucleoplasmic Viscosity by Fluorescence Correlation Spectroscopy”, Journal of Biomedical Optics, 14, 024013, 2009.

48. Shengnan Wu, Da Xing, Xuejuan Gao, and Wei R. Chen, “High fluence low-power laser irradiation induces mitochondrial permeability transition mediated by reactive oxygen species”, Journal of Cellular Physiology, 218(3), 603-611, March 2009.

49. Sheng Song, Feifan Zhou, Robert E. Nordquist, Raoul Carubelli, Hong Liu, and Wei R. Chen, “Glycated chitosan as a new non-toxic immunological stimulant”, Immunopharmacology and Immunotoxicology, 31(2), 202–208, 2009.

50. Feifan Zhou, Da Xing, and Wei R. Chen, “Single Cell Imaging of Bax Translocation during Apoptosis Induced by Photofrin-PDT”, Journal of Innovative Optical Health Sciences, 2, 209-214, 2009.

51. Feifan Zhou, Da Xing, and Wei R. Chen, “Regulation of HSP70 on activating macrophages using PDT-induced apoptotic cells”, International Journal of Cancer, 125, 1380-1389, 2009.

52. Xianwang Wang, Da Xing, Lei Liu, and Wei R. Chen, “BimL directly neutralizes Bcl-xL to promote Bax activation during UV-induced apoptosis”, FEBS Letters 583 (12), 1873-1879, 2009.

53. Lei Liu, Da Xing, and Wei R. Chen, “-Calpain mediates caspase-dependent and -independent apoptotic pathways in cisplatin-induced apoptosis”, International Journal of Cancer, 125 (12), 2757-2766, 2009.

54. Xiaoming Zhou, Da Xing, Yonghong Tang, and Wei R. Chen, “PCR-Free Detection of Genetically Modified Organisms Using Magnetic Capture Technology and Fluorescence Cross-Correlation Spectroscopy”, PLoS ONE, 4(11): e8074. doi:10.1371/journal.pone.0008074, 2009.

55. Feifan Zhou, Da Xing, Shengnan Wu, and Wei R. Chen, “Intravital imaging of tumor apoptosis with FRET probes during tumor therapy”, Molecular Imaging and Biology, 12, 63-70, 2010.

56. Feifan Zhou, Da Xing, Baoyan Wu, Shengnan Wu, Zhongmin Ou, and Wei R. Chen, “New insights of transmembranal mechanism and subcellular localization of noncovalently modified single-walled carbon nanotubes”, Nano Letters, 10, 1677-1681, 2010.

57. Yunlong Li, Da Xing, Qun Chen, and Wei R. Chen, “Enhancement of Chemotherapeutic Agent-Induced Apoptosis by Inhibition of NF-κB Using Ursolic Acid”, International Journal of Cancer, 127, 462-473, 2010.

58. Xiaosong Li, Tomas Hode, Maria C. Guerra, Gabriela L. Ferrel, John A. Lunn, Orn Adalsteinsson, Robert E. Nordquist, and Wei R. Chen, “Combined effects of selective photothermal therapy and immunoadjuvant against Stage IV breast cancer”, Journal of Innovative Optical Health Science, 3, 279-284, 2010.

59. Hui Li, Lei Liu, Da Xing, and Wei R. Chen, “Inhibition of JNK/Bim Pathway by Hsp70 Prevents Bax Activation in UV-induced Apoptosis”, FEBS Letters, 84(22), 4672-4678, 2010.

60. Xiaosong Li, Mark F. Naylor, Robert E. Nordquist, T. Kent Teague, C. Anthony Howard, Cynthia Murray, and Wei R. Chen, “In Situ Photoimmunotherapy for Late-stage Melanoma Patients: a Preliminary Study”, Cancer Biology and Therapy, 10(11), 1077-1214, 2010.

61. Xiaosong Li, Henry Le, Roman F. Wolf, Vivian A. Chen, Akhee Sarkar, Robert E. Nordquist, Halie Ferguson, Hong Liu, and Wei R. Chen, “Long-Term Effect on EMT6 Tumors in Mice Induced by Combination of Laser Immunotherapy and Surgery”, Integrative Cancer Therapies, DOI: 10.1177/1534735410387597, 2010.

62. Xiaosong Li and Wei R. Chen, “Laser Immunotherapy: Novel Modality to Treat Cancer through Specific Antitumor Immune Response”, Chinese Journal of Lasers, 37(11), 2698-2702, 2010.

63. Xiaosong Li, Gabriela L. Ferrel, Maria C. Guerra, Tomas Hode, John A. Lunn, Orn Adalsteinsson, Robert E. Nordquist, Hong Liu, and Wei R. Chen, “Preliminary safety and efficacy results of laser immunotherapy for the treatment of metastatic breast cancer patients”, Photochemical & Photobiological Sciences, 10, 817-821, 2011.

64. Xiaohui Zheng, Da Xing, Feifan Zhou, Baoyan Wu, and Wei R. Chen, “Indocyanine Green-Containing Nanostructure as Near Infrared Dual-Functional Targeting Probes for Optical Imaging and Photothermal Therapy”, Molecular Pharmaceutics, 8, 447-456, 2011.